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Issue 20, 2016
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Enzymatic induction of supramolecular order and bioactivity

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We showed in this study that enzymatic triggering is a totally different pathway for the preparation of self-assembling nanomaterials to the heating–cooling process. Because the molecules were under lower energy levels and the molecular conformation was more ordered during the enzymatic triggeration under mild conditions, nanomaterials with higher supramolecular order could be obtained through biocatalytic control. In this study, nanoparticles were obtained by an enzymatic reaction and nanofibers were observed through the heating–cooling process. We observed a distinct trough at 318 nm from the CD spectrum of a particle sample but not a fiber sample, suggesting the long range arrangement of molecules and helicity in the nanoparticles. The nanoparticles with higher supramolecular order possessed much better potency as a protein vaccine adjuvant because it accelerated the DC maturation and elicited stronger T-cells cytokine production than the nanofibers. Our study demonstrated that biocatalytic triggering is a useful method for preparing supramolecular nanomaterials with higher supramolecular order and probably better bioactivity.

Graphical abstract: Enzymatic induction of supramolecular order and bioactivity

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Supplementary files

Article information

21 Mar 2016
22 Apr 2016
First published
26 Apr 2016

Nanoscale, 2016,8, 10768-10773
Article type

Enzymatic induction of supramolecular order and bioactivity

C. Yang, X. Ren, D. Ding, L. Wang and Z. Yang, Nanoscale, 2016, 8, 10768
DOI: 10.1039/C6NR02330D

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