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Issue 10, 2016
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Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities

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Abstract

Covering: up to 2016

Antimycin-type depsipeptides are a family of natural products with great structural diversity and outstanding biological activities. These compounds have typically been isolated from actinomycetes and are generated from hybrid nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) assembly lines. This review covers the literature on the four classes of antimycin-type depsipeptides, which differ by macrolactone ring size, and it discusses the discovery, biosynthesis, chemical synthesis, and biological activities of this family of compounds.

Graphical abstract: Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities

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Article information


Submitted
09 Jan 2016
First published
16 Jun 2016

Nat. Prod. Rep., 2016,33, 1146-1165
Article type
Review Article

Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities

J. Liu, X. Zhu, S. J. Kim and W. Zhang, Nat. Prod. Rep., 2016, 33, 1146
DOI: 10.1039/C6NP00004E

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