Issue 10, 2016
From the journal:

Natural Product Reports

Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities

Joyce Liu,a   Xuejun Zhu,b   Seong Jong Kimb  and  Wenjun Zhang*bc  

* Corresponding authors

a Department of Bioengineering, University of California, Berkeley, California, USA

b Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California, USA
E-mail: wjzhang@berkeley.edu

c Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA

Abstract

Covering: up to 2016

Antimycin-type depsipeptides are a family of natural products with great structural diversity and outstanding biological activities. These compounds have typically been isolated from actinomycetes and are generated from hybrid nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) assembly lines. This review covers the literature on the four classes of antimycin-type depsipeptides, which differ by macrolactone ring size, and it discusses the discovery, biosynthesis, chemical synthesis, and biological activities of this family of compounds.

Graphical abstract: Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities

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Article information

DOI
https://doi.org/10.1039/C6NP00004E
Article type
Review Article
Submitted
09 Jan 2016
First published
16 Jun 2016

Nat. Prod. Rep., 2016,33, 1146-1165

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Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities

J. Liu, X. Zhu, S. J. Kim and W. Zhang, Nat. Prod. Rep., 2016, 33, 1146 DOI: 10.1039/C6NP00004E

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