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Issue 2, 2016
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Recent advances in the biosynthesis of unusual polyketide synthase substrates

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Abstract

Covering: 2003 to July 2015 for polyketide synthase starter units and 2012 to September 2015 for polyketide synthase extender units

This highlight provides an overview of recent advances in understanding the diversity of polyketide synthase (PKS) substrate building blocks. Substrates functioning as starter units and extender units contribute significantly to the chemical complexity and structural diversity exhibited by this class of natural products. This article complements and extends upon the current comprehensive reviews that have been published on these two topics (Moore and Hertweck, Nat. Prod. Rep., 2002, 19, 70; Chan et al., Nat. Prod. Rep., 2009, 1, 90; Wilson and Moore, Nat. Prod. Rep., 2012, 29, 72).

Graphical abstract: Recent advances in the biosynthesis of unusual polyketide synthase substrates

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Article information


Submitted
11 Sep 2015
First published
16 Nov 2015

Nat. Prod. Rep., 2016,33, 150-161
Article type
Highlight

Recent advances in the biosynthesis of unusual polyketide synthase substrates

L. Ray and B. S. Moore, Nat. Prod. Rep., 2016, 33, 150
DOI: 10.1039/C5NP00112A

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