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Issue 4, 2016
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Activity-based assessment of an engineered hyperthermophilic protein as a capture agent in paper-based diagnostic tests

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Abstract

Antibodies have traditionally served as the affinity reagents of choice in point-of-care diagnostic biosensors. However, this class of proteins is not ideally suited for this use, being poorly characterized and prone to thermal denaturation. Here, we present an activity-based assessment of an alternative engineered binding protein in a cellulose-based assay.

Graphical abstract: Activity-based assessment of an engineered hyperthermophilic protein as a capture agent in paper-based diagnostic tests

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Article information


Submitted
31 Mar 2016
Accepted
17 Jun 2016
First published
29 Jun 2016

Mol. Syst. Des. Eng., 2016,1, 377-381
Article type
Communication

Activity-based assessment of an engineered hyperthermophilic protein as a capture agent in paper-based diagnostic tests

E. A. Miller, M. W. Traxlmayr, J. Shen and H. D. Sikes, Mol. Syst. Des. Eng., 2016, 1, 377
DOI: 10.1039/C6ME00032K

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