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A microwave-assisted method for the synthesis of tetracyclic tetrahydropyridines via an intramolecular imino-Diels–Alder reaction in water is reported. The reaction proceeds under catalyst-free conditions and shows excellent stereoselectivity.

Graphical abstract: Highly stereoselective and catalyst-free synthesis of annulated tetrahydropyridines by intramolecular imino-Diels–Alder reaction under microwave irradiation in water

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