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Issue 13, 2016
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An efficient Passerini tetrazole reaction (PT-3CR)

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Abstract

A sonication accelerated, catalyst free, simple, high yielding and efficient method for the Passerini-type three-component reaction (PT-3CR) has been developed. It comprises the reaction of an aldehyde/ketone, an isocyanide and a TMS-azide in methanol : water (1 : 1) as the solvent system. The use of sonication not only accelerated the rate of the reaction but also provided good to excellent quantitative yields. This reaction is applicable to a broad scope of aldehydes/ketones and isocyanides.

Graphical abstract: An efficient Passerini tetrazole reaction (PT-3CR)

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Publication details

The article was received on 31 Mar 2016, accepted on 19 May 2016 and first published on 19 May 2016


Article type: Communication
DOI: 10.1039/C6GC00910G
Green Chem., 2016,18, 3718-3721
  • Open access: Creative Commons BY-NC license
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    An efficient Passerini tetrazole reaction (PT-3CR)

    A. L. Chandgude and A. Dömling, Green Chem., 2016, 18, 3718
    DOI: 10.1039/C6GC00910G

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