Issue 6, 2016

Eucommia ulmoides extracts prevent the formation of advanced glycation end products

Abstract

Proteins non-enzymatically react with reducing sugars to form advanced glycation end-products (AGEs), resulting in the induction of protein denaturation. Because the levels of AGE increase with age and are elevated in age-related diseases, such as diabetes and atherosclerosis, the intake of compound(s) that inhibit the formation of AGEs by daily meal may represent a potential strategy for preventing age-related diseases. In this study, we measured the inhibitory effects of several Eucommia ulmoides extracts on the formation of AGEs, Nε-(carboxymethyl)lysine (CML) and Nω-(carboxymethyl)arginine (CMA). Although a crude extract obtained from E. ulmoides bark is widely used as herbal medicine, E. ulmoides leaf extract (ELE) inhibited CML and CMA formation more effectively during the incubation of gelatin with ribose. Therefore, the inhibitory effects of compounds present in ELE on CML and CMA formation were studied. As a result, isoquercetin showed the strongest inhibitory effect of all the tested ELE components. These results indicate that the oral intake of ELE may inhibit the formation of AGEs, thereby ameliorating age-related diseases.

Graphical abstract: Eucommia ulmoides extracts prevent the formation of advanced glycation end products

Article information

Article type
Paper
Submitted
15 Dec 2015
Accepted
22 Mar 2016
First published
15 Apr 2016

Food Funct., 2016,7, 2566-2573

Author version available

Eucommia ulmoides extracts prevent the formation of advanced glycation end products

H. Sugawa, R. Ohno, J. Shirakawa, A. Nakajima, A. Kanagawa, T. Hirata, T. Ikeda, N. Moroishi, M. Nagai and R. Nagai, Food Funct., 2016, 7, 2566 DOI: 10.1039/C5FO01563D

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