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Issue 99, 2016
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Palladium-mediated in situ synthesis of an anticancer agent

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Abstract

As a novel prodrug activation strategy Pd(0) nanoparticles, entrapped within a modular polymeric support, were used in cell culture, to synthesise the anticancer agent PP-121 from two non-toxic precursors, thereby inducing cell death in the first example of in situ mediated drug synthesis.

Graphical abstract: Palladium-mediated in situ synthesis of an anticancer agent

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Article information


Submitted
28 Oct 2016
Accepted
16 Nov 2016
First published
25 Nov 2016

Chem. Commun., 2016,52, 14212-14214
Article type
Communication

Palladium-mediated in situ synthesis of an anticancer agent

E. Indrigo, J. Clavadetscher, S. V. Chankeshwara, A. Lilienkampf and M. Bradley, Chem. Commun., 2016, 52, 14212
DOI: 10.1039/C6CC08666G

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