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Issue 85, 2016
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Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers

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Abstract

We report that a G-quadruplex-specific compound induced structural changes in G-quadruplex-forming DNA aptamers and stabilized the folded structures, making them suitable for targeted proteins and enhancing their binding properties.

Graphical abstract: Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers

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Supplementary files

Article information


Submitted
16 Sep 2016
Accepted
29 Sep 2016
First published
30 Sep 2016

Chem. Commun., 2016,52, 12646-12649
Article type
Communication

Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers

K. Tsukakoshi, Y. Ikuta, K. Abe, W. Yoshida, K. Iida, Y. Ma, K. Nagasawa, K. Sode and K. Ikebukuro, Chem. Commun., 2016, 52, 12646
DOI: 10.1039/C6CC07552E

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