A catalytic methodology for the conversion of amides to amines is reported. Of the 25 examples described, 14 examples involve the reduction of N-trifluoroacetamides to the corresponding trifluoroethylamines. These reductions are achieved by catalytic hydrosilylation of the amide mediated by an electrophilic phosphonium cation (EPC) catalyst.
A. Augurusa, M. Mehta, M. Perez, J. Zhu and D. W. Stephan, Chem. Commun., 2016, 52, 12195 DOI: 10.1039/C6CC06914B
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