Issue 70, 2016
From the journal:

Chemical Communications

Catalytic enantio- and diastereoselective Mannich reaction of α-substituted isocyanoacetates and ketimines†

Raquel de la Campa,a   Adam D. Gammack Yamagata,a   Irene Ortín,a   Allegra Franchino,a   Amber L. Thompson,a   Barbara Odella  and  Darren J. Dixon*a  

* Corresponding authors

a Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK
E-mail: darren.dixon@chem.ox.ac.uk

Abstract

The highly diastereo- and enantioselective Mannich addition/cyclisation reaction of α-substituted isocyanoacetate ester pronucleophiles and (hetero)aryl and alkyl methyl ketone-derived ketimines using a silver acetate and a cinchona-derived amino phosphine binary catalyst system is reported.

Graphical abstract: Catalytic enantio- and diastereoselective Mannich reaction of α-substituted isocyanoacetates and ketimines

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Article information

DOI
https://doi.org/10.1039/C6CC04132A
Article type
Communication
Submitted
16 May 2016
Accepted
01 Aug 2016
First published
01 Aug 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 10632-10635

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Catalytic enantio- and diastereoselective Mannich reaction of α-substituted isocyanoacetates and ketimines

R. de la Campa, A. D. Gammack Yamagata, I. Ortín, A. Franchino, A. L. Thompson, B. Odell and D. J. Dixon, Chem. Commun., 2016, 52, 10632 DOI: 10.1039/C6CC04132A

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