Issue 70, 2016

An annulative transfer hydrogenation strategy enables straightforward access to tetrahydro fused-pyrazine derivatives

Abstract

A ruthenium-catalysed annulative transfer hydrogenation strategy, enabling straightforward access to tetrahydro fused-pyrazine derivatives from N-heteroaryl diamines and vicinal diols, has been demonstrated for the first time. Such a synthesis proceeds with unprecedented synthetic effectiveness including high step- and atom efficiency, generation of water as the sole by-product, short reaction time and no need for external high pressure H2 gas, offering an important basis for the transformation of vicinal diols, a class of bio-mass derived resources, into functionalized products.

Graphical abstract: An annulative transfer hydrogenation strategy enables straightforward access to tetrahydro fused-pyrazine derivatives

Supplementary files

Article information

Article type
Communication
Submitted
27 Jun 2016
Accepted
02 Aug 2016
First published
02 Aug 2016

Chem. Commun., 2016,52, 10636-10639

An annulative transfer hydrogenation strategy enables straightforward access to tetrahydro fused-pyrazine derivatives

B. Xiong, S. Zhang, L. Chen, B. Li, H. Jiang and M. Zhang, Chem. Commun., 2016, 52, 10636 DOI: 10.1039/C6CC05329G

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