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Issue 33, 2016
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Biosensing made easy with PEG-targeted bi-specific antibodies

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Abstract

Whilst recent advances in nanotechnology have yielded many new biosensing capabilities, innovative biological attachment and detection modalities remain relatively underdeveloped. Bi-specific antibodies (bsAbs) – which exhibit binding capability for two separate targets – offer an inherent advantage over conventional antibody reagents by significantly simplifying sensor surface preparation. Herein, we report the deployment of bsAbs for simultaneous attachment to a polymer-coated transducer and label-free, electrochemical (EC) detection of target antigens.

Graphical abstract: Biosensing made easy with PEG-targeted bi-specific antibodies

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Article information


Submitted
03 Mar 2016
Accepted
31 Mar 2016
First published
31 Mar 2016

Chem. Commun., 2016,52, 5730-5733
Article type
Communication

Biosensing made easy with PEG-targeted bi-specific antibodies

L. J. Raftery, Y. S. Grewal, C. B. Howard, M. L. Jones, M. J. A. Shiddiky, L. G. Carrascosa, K. J. Thurecht, S. M. Mahler and M. Trau, Chem. Commun., 2016, 52, 5730
DOI: 10.1039/C6CC01916A

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