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Issue 33, 2016
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Enantioselective intramolecular cyclization of alkynyl esters catalyzed by a chiral Brønsted base

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Abstract

An enantioselective intramolecular cyclization reaction of alkynyl esters was developed, which employs a Brønsted base catalyst generated in situ from a chiral Schiff base and t-BuOK. This reaction is a rare example of the enantioselective intramolecular addition of simple ester enolates to alkynes under Brønsted base catalysis.

Graphical abstract: Enantioselective intramolecular cyclization of alkynyl esters catalyzed by a chiral Brønsted base

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Article information


Submitted
24 Feb 2016
Accepted
23 Mar 2016
First published
25 Mar 2016

Chem. Commun., 2016,52, 5726-5729
Article type
Communication

Enantioselective intramolecular cyclization of alkynyl esters catalyzed by a chiral Brønsted base

A. Kondoh, H. T. Q. Tran, K. Kimura and M. Terada, Chem. Commun., 2016, 52, 5726
DOI: 10.1039/C6CC01690A

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