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Issue 58, 2016
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Bioreductive fluorescent imaging agents: applications to tumour hypoxia

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Abstract

Large tumours contain regions with very low intracellular O2 concentrations. Known as hypoxia, this feature of tumours yields a highly reducing environment owing to the presence of numerous oxygen sensitive reductase enzymes. The development of new optical chemosensors for these various reductases presents an ideal approach to visualise areas of hypoxia or highly reducing environments. Critical to the success of such chemosensors is the design of probes containing a bioreductively activated moiety that either ensures the selective retention of fluorescence within a hypoxic tissue or a probe that irreversibly releases a reporter fluorophore. This Feature Article aims to summarise the fluorescent tools that have been developed to image tumour hypoxia and the various reductase enzymes associated with the bioreduction process.

Graphical abstract: Bioreductive fluorescent imaging agents: applications to tumour hypoxia

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Publication details

The article was received on 01 Feb 2016, accepted on 19 Feb 2016 and first published on 19 Feb 2016


Article type: Feature Article
DOI: 10.1039/C6CC01037G
Chem. Commun., 2016,52, 8935-8956

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    Bioreductive fluorescent imaging agents: applications to tumour hypoxia

    R. B. P. Elmes, Chem. Commun., 2016, 52, 8935
    DOI: 10.1039/C6CC01037G

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