Issue 9, 2016
From the journal:

Chemical Communications

Catalytic reductive N-alkylation of amines using carboxylic acids†

Keith G. Andrews,a   Declan M. Summers,a   Liam J. Donnellya  and  Ross M. Denton*a  

* Corresponding authors

a School of Chemistry, University Park, University of Nottingham, Nottingham, UK
E-mail: ross.denton@nottingham.ac.uk

Abstract

We report a catalytic reductive alkylation reaction of primary or secondary amines with carboxylic acids. The two-phase process involves silane mediated direct amidation followed by catalytic reduction.

Graphical abstract: Catalytic reductive N-alkylation of amines using carboxylic acids

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Article information

DOI
https://doi.org/10.1039/C5CC08881J
Article type
Communication
Submitted
26 Oct 2015
Accepted
03 Dec 2015
First published
03 Dec 2015

Chem. Commun., 2016,52, 1855-1858

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Catalytic reductive N-alkylation of amines using carboxylic acids

K. G. Andrews, D. M. Summers, L. J. Donnelly and R. M. Denton, Chem. Commun., 2016, 52, 1855 DOI: 10.1039/C5CC08881J

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