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Issue 9, 2016
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Catalytic reductive N-alkylation of amines using carboxylic acids

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Abstract

We report a catalytic reductive alkylation reaction of primary or secondary amines with carboxylic acids. The two-phase process involves silane mediated direct amidation followed by catalytic reduction.

Graphical abstract: Catalytic reductive N-alkylation of amines using carboxylic acids

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Supplementary files

Article information


Submitted
26 Oct 2015
Accepted
03 Dec 2015
First published
03 Dec 2015

Chem. Commun., 2016,52, 1855-1858
Article type
Communication
Author version available

Catalytic reductive N-alkylation of amines using carboxylic acids

K. G. Andrews, D. M. Summers, L. J. Donnelly and R. M. Denton, Chem. Commun., 2016, 52, 1855
DOI: 10.1039/C5CC08881J

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