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Issue 4, 2016
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Naphthalimide-based fluorescent probe for selectively and specifically detecting glutathione in the lysosomes of living cells

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Abstract

A novel naphthalimide-based fluorescent probe employing a sulfonamide unit as a thiol-responsive group is reported. It is capable of efficiently distinguishing GSH from cysteine and homocysteine. Bioimaging shows that it has high selectivity in living cells and can visualize the level of GSH in lysosomes. It is worth mentioning that different groups on the imide unit can affect the selectivity and reaction dynamics of the probe towards thiols.

Graphical abstract: Naphthalimide-based fluorescent probe for selectively and specifically detecting glutathione in the lysosomes of living cells

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Publication details

The article was received on 07 Oct 2015, accepted on 09 Nov 2015 and first published on 11 Nov 2015


Article type: Communication
DOI: 10.1039/C5CC08328A
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Chem. Commun., 2016,52, 721-724

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    Naphthalimide-based fluorescent probe for selectively and specifically detecting glutathione in the lysosomes of living cells

    M. Cao, H. Chen, D. Chen, Z. Xu, S. H. Liu, X. Chen and J. Yin, Chem. Commun., 2016, 52, 721
    DOI: 10.1039/C5CC08328A

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