Issue 6, 2016
From the journal:

Biomaterials Science

Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration†

Masao Kamimura,a   Michiko Sugawara,b   Shota Yamamoto,c   Kazuo Yamaguchic  and  Jun Nakanishi*a  

* Corresponding authors

a WPI Research Center Initiative, International Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan
E-mail: NAKANISHI.Jun@nims.go.jp

b Department of Mechanical Engineering, Graduate School of Engineering, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan

c Department of Chemistry, Faculty of Science, Research Institute for Photofunctionalized Materials, Kanagawa University, 2946 Tsuchiya, Hiratsuka, Kanagawa 259-1293, Japan

Abstract

A method was developed for photocontrolling cell adhesion on a gel substrate with defined mechanical properties. Precise patterning of geometrically controlled cell clusters and their migration induction became possible by spatiotemporally controlled photo-irradiation of the substrate. The clusters exhibited unique collective motion that depended on substrate stiffness and cluster geometry.

Graphical abstract: Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6BM00100A
Article type
Communication
Submitted
09 Feb 2016
Accepted
29 Mar 2016
First published
06 Apr 2016
This article is Open Access
Creative Commons BY-NC license

Biomater. Sci., 2016,4, 933-937

Permissions

Request permissions

Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration

M. Kamimura, M. Sugawara, S. Yamamoto, K. Yamaguchi and J. Nakanishi, Biomater. Sci., 2016, 4, 933 DOI: 10.1039/C6BM00100A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements