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Issue 4, 2016
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Resonant X-ray emission spectroscopy of platinum(ii) anticancer complexes

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Platinum-based drugs are commonly used in cancer treatment. The biological activity of a metallodrug is obviously closely related to its chemical and stereochemical characteristics. An overlooked aspect is the effect of the ligand to the electronic structure of the metal atom (coordinated atom). We report herein a Resonant X-ray Emission Spectroscopy (RXES) study on the chemical speciation of chiral platinum complexes in which diastereomers are distinguished on the basis of their metal electronic configuration. This demonstrates RXES high chemical speciation capabilities, a necessary property to further investigate the reactivity of the Pt atom towards nucleophiles or bionucleophiles, and an important complement the previously reported RXES abilities, namely that it can be employed for in situ studies at physiological concentrations.

Graphical abstract: Resonant X-ray emission spectroscopy of platinum(ii) anticancer complexes

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Supplementary files

Article information

04 Dec 2015
18 Jan 2016
First published
18 Jan 2016

Analyst, 2016,141, 1226-1232
Article type

Resonant X-ray emission spectroscopy of platinum(II) anticancer complexes

J. Sá, J. Czapla-Masztafiak, E. Lipiec, Y. Kayser, D. L. A. Fernandes, J. Szlachetko, F. Dufrasne and G. Berger, Analyst, 2016, 141, 1226
DOI: 10.1039/C5AN02490K

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