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Issue 115, 2016, Issue in Progress
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Magnetic iron nanoparticles for in vivo targeted delivery and as biocompatible contrast agents

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Abstract

Iron nanoparticles (NPs) of size less than 20 nm were synthesized using an in-house developed cryomill. These NPs exhibit values of saturation magnetisation (∼180 emu g−1) close to that of pure iron. The particles were found to be nontoxic at concentrations required for MRI imaging as indicated by MTT assay. In vivo studies demonstrated the suitability of using these particles as contrast agents for MRI. The iron NPs were bio-capped with TRITC–dextran and injected into mice to study the transport behavior of the NPs under the influence of an external magnetic field. The iron NPs showed enhanced aggregation and contrast when a bar magnet was placed on the mice as observed by whole body fluorescence imaging.

Graphical abstract: Magnetic iron nanoparticles for in vivo targeted delivery and as biocompatible contrast agents

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Article information


Submitted
07 Jun 2016
Accepted
01 Dec 2016
First published
02 Dec 2016

RSC Adv., 2016,6, 114344-114352
Article type
Communication

Magnetic iron nanoparticles for in vivo targeted delivery and as biocompatible contrast agents

C. S. Tiwary, R. J. Mudakavi, S. Kishore, S. Kashyap, R. Elumalai, D. Chakravortty, Ashok M. Raichur and K. Chattopadhyay, RSC Adv., 2016, 6, 114344
DOI: 10.1039/C6RA14817D

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