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Issue 41, 2016
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Total synthesis of wewakazole B

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Wewakazole B is a novel cyclodecapeptide with highly potent cytotoxic activity isolated from a sample of M. producens collected from the Red Sea. It contains nine common and three modified amino acid residues. The first total synthesis of Wewakazole B was successfully achieved on a gram scale, unambiguously confirming its structure. Notable features include the careful choice of amino acid-protecting groups and the construction of three different substituted oxazoles present in this natural product.

Graphical abstract: Total synthesis of wewakazole B

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Supplementary files

Article information

16 Aug 2016
28 Sep 2016
First published
28 Sep 2016

Org. Biomol. Chem., 2016,14, 9712-9715
Article type

Total synthesis of wewakazole B

B. Long, J. Zhang, X. Tang and Z. Wu, Org. Biomol. Chem., 2016, 14, 9712
DOI: 10.1039/C6OB01783E

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