Jump to main content
Jump to site search

Issue 3, 2016
Previous Article Next Article

An exothermic chip for point-of-care testing using a forehead thermometer as a readout

Author affiliations

Abstract

We report an exothermic chip for quantitative point-of-care testing using a forehead thermometer as a readout. The chip has a capillary channel that directs an aqueous sample into an exothermic reservoir. NaOH powders are preloaded in the reservoir as the exothermic reagent. At the inlet of the capillary channel, a microvalve is fabricated using an aptamer-modified hydrogel which is responsive to a specific analyte. When the aqueous sample comes in contact with the hydrogel valve, the hydrogel shrinks due to the selective analyte–hydrogel interaction. The volume reduction of the hydrogel increases the capillary flow rate, and thus increases the heat produced by NaOH dissolution. A forehead thermometer is used to measure the temperature increment which is correlated with the analyte concentration. Using this method, heavy metal ions (Hg2+ and Pb2+) in different real samples are quantitatively analyzed.

Graphical abstract: An exothermic chip for point-of-care testing using a forehead thermometer as a readout

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Sep 2015, accepted on 14 Dec 2015 and first published on 14 Dec 2015


Article type: Paper
DOI: 10.1039/C5LC01136A
Citation: Lab Chip, 2016,16, 525-531
  •   Request permissions

    An exothermic chip for point-of-care testing using a forehead thermometer as a readout

    B. Gao, H. Liu and Z. Gu, Lab Chip, 2016, 16, 525
    DOI: 10.1039/C5LC01136A

Search articles by author

Spotlight

Advertisements