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Issue 3, 2016
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An exothermic chip for point-of-care testing using a forehead thermometer as a readout

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Abstract

We report an exothermic chip for quantitative point-of-care testing using a forehead thermometer as a readout. The chip has a capillary channel that directs an aqueous sample into an exothermic reservoir. NaOH powders are preloaded in the reservoir as the exothermic reagent. At the inlet of the capillary channel, a microvalve is fabricated using an aptamer-modified hydrogel which is responsive to a specific analyte. When the aqueous sample comes in contact with the hydrogel valve, the hydrogel shrinks due to the selective analyte–hydrogel interaction. The volume reduction of the hydrogel increases the capillary flow rate, and thus increases the heat produced by NaOH dissolution. A forehead thermometer is used to measure the temperature increment which is correlated with the analyte concentration. Using this method, heavy metal ions (Hg2+ and Pb2+) in different real samples are quantitatively analyzed.

Graphical abstract: An exothermic chip for point-of-care testing using a forehead thermometer as a readout

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Article information


Submitted
21 Sep 2015
Accepted
14 Dec 2015
First published
14 Dec 2015

Lab Chip, 2016,16, 525-531
Article type
Paper

An exothermic chip for point-of-care testing using a forehead thermometer as a readout

B. Gao, H. Liu and Z. Gu, Lab Chip, 2016, 16, 525
DOI: 10.1039/C5LC01136A

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