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Issue 43, 2016
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Ionic liquid induced G-quadruplex formation and stabilization: spectroscopic and simulation studies

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Abstract

Among different polymorphs of DNA, G-quadruplex (GQ) formation in guanine rich sequences has received special attention due to its direct relevance to cellular aging and abnormal cell growths. To date, smaller ions like Na+, K+, Li+, and NH4+ are the best possible selective GQ stabilizing materials. Herein, we report that an ionic liquid (IL), i.e. guanidinium tris(pentafluoroethyl)trifluorophosphate, can not only instigate the GQ formation in the absence of conventional GQ forming ions (like Na+, K+, NH4+, etc.), but also stabilizes the GQ structure. This conformational transition has been confirmed through different spectroscopic tools and molecular dynamics (MD) simulation studies. MD simulation shows that one of the guanidinium cations resides in the G-tetrad core, while bulky anions prefer to stay near the GQ surface resulting in GQ formation and stabilization. This study thus brings out a special type of ionic liquid that acts as a GQ stabilizer. The origin of GQ stabilization by IL presented here may also help in the future design of IL for GQ formation and stabilization.

Graphical abstract: Ionic liquid induced G-quadruplex formation and stabilization: spectroscopic and simulation studies

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Supplementary files

Article information


Submitted
18 Aug 2016
Accepted
29 Sep 2016
First published
06 Oct 2016

Phys. Chem. Chem. Phys., 2016,18, 29740-29746
Article type
Paper

Ionic liquid induced G-quadruplex formation and stabilization: spectroscopic and simulation studies

S. Satpathi, M. Kulkarni, A. Mukherjee and P. Hazra, Phys. Chem. Chem. Phys., 2016, 18, 29740
DOI: 10.1039/C6CP05732B

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