Issue 36, 2016

Long-lived states to sustain SABRE hyperpolarised magnetisation


The applicability of the magnetic resonance (MR) technique in the liquid phase is limited by poor sensitivity and short nuclear spin coherence times which are insufficient for many potential applications. Here we illustrate how it is possible to address both of these issues simultaneously by harnessing long-lived hyperpolarised spin states that are formed by adapting the Signal Amplification by Reversible Exchange (SABRE) technique. We achieve more than 4% net 1H-polarisation in a long-lived form that remains detectable for over ninety seconds by reference to proton pairs in the biologically important molecule nicotinamide and a pyrazine derivative whose in vivo imaging will offer a new route to probe disease in the future.

Graphical abstract: Long-lived states to sustain SABRE hyperpolarised magnetisation

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Article information

Article type
28 Apr 2016
15 Aug 2016
First published
15 Aug 2016
This article is Open Access
Creative Commons BY license

Phys. Chem. Chem. Phys., 2016,18, 24905-24911

Long-lived states to sustain SABRE hyperpolarised magnetisation

S. S. Roy, P. J. Rayner, P. Norcott, G. G. R. Green and S. B. Duckett, Phys. Chem. Chem. Phys., 2016, 18, 24905 DOI: 10.1039/C6CP02844F

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