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Issue 88, 2016

Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation†

Naatasha Isahak,a   Guillaume Gody,b   Lara R. Malins,a   Nicholas J. Mitchell,a   Richard J. Payne*a  and  Sébastien Perrier ORCID logo *abc  
Author affiliations

* Corresponding authors

a School of Chemistry, The University of Sydney, NSW 2006, Australia
E-mail: richard.payne@sydney.edu.au

b Department of Chemistry, The University of Warwick, Coventry, UK
E-mail: s.perrier@warwick.ac.uk

c Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Australia

Abstract

A novel method for the introduction of a single protected amine-functional monomer at the chain end of RAFT polymers has been developed. This monomer addition, in concert with native chemical ligation, facilitated the development of a simple and versatile method for the end-functionalization of polymers with peptides.

Graphical abstract: Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation

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Article information

https://doi.org/10.1039/C6CC06010B
Submitted
21 Jul 2016
Accepted
21 Sep 2016
First published
23 Sep 2016
Chem. Commun., 2016,52, 12952-12955
Article type
Communication
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Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation

N. Isahak, G. Gody, L. R. Malins, N. J. Mitchell, R. J. Payne and S. Perrier, Chem. Commun., 2016, 52, 12952 DOI: 10.1039/C6CC06010B

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