Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation

Naatasha Isahak; Guillaume Gody; Lara R. Malins; Nicholas J. Mitchell; Richard J. Payne; Sébastien Perrier

doi:10.1039/C6CC06010B

Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation†

Naatasha Isahak,^a Guillaume Gody,^b Lara R. Malins,^a Nicholas J. Mitchell,^a Richard J. Payne*^a and Sébastien Perrier

*^abc

Author affiliations

* Corresponding authors

^a School of Chemistry, The University of Sydney, NSW 2006, Australia
E-mail: richard.payne@sydney.edu.au

^b Department of Chemistry, The University of Warwick, Coventry, UK
E-mail: s.perrier@warwick.ac.uk

^c Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Australia

Abstract

A novel method for the introduction of a single protected amine-functional monomer at the chain end of RAFT polymers has been developed. This monomer addition, in concert with native chemical ligation, facilitated the development of a simple and versatile method for the end-functionalization of polymers with peptides.

Supplementary files

Publication details

The article was received on 21 Jul 2016, accepted on 21 Sep 2016 and first published on 23 Sep 2016

Article type: Communication

DOI: 10.1039/C6CC06010B

Citation: Chem. Commun., 2016,52, 12952-12955

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Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation

N. Isahak, G. Gody, L. R. Malins, N. J. Mitchell, R. J. Payne and S. Perrier, Chem. Commun., 2016, 52, 12952
DOI: 10.1039/C6CC06010B
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Chemical Communications

Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation†

Abstract

Supplementary files

Publication details

Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation

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