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Issue 31, 2016
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Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

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Abstract

Using the HIF-1α transcription factor as a model, this manuscript illustrates how an extended sequence of α-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an α-helix comprised from an aromatic oligoamide. The resultant hybrid is capable of reproducing the molecular recognition profile of the p300 binding sequence of HIF-1α from which it is derived.

Graphical abstract: Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

  • This article is part of the themed collection: Foldamers
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Article information


Submitted
29 Feb 2016
Accepted
11 Mar 2016
First published
24 Mar 2016

This article is Open Access

Chem. Commun., 2016,52, 5421-5424
Article type
Communication
Author version available

Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

G. M. Burslem, H. F. Kyle, A. L. Breeze, T. A. Edwards, A. Nelson, S. L. Warriner and A. J. Wilson, Chem. Commun., 2016, 52, 5421
DOI: 10.1039/C6CC01812B

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