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Issue 22, 2016
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Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication

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Abstract

3,4-Diaminopyridine has shown promise in reversing botulinum intoxication, but poor pharmacokinetics and a narrow therapeutic window limit its clinical utility. Thus, we developed a pH-dependent oral delivery platform using club moss spore exines. These exine microcapsules slowed 3,4-diaminopyridine absorption, limited its seizure activity, and enabled delivery of doses which prolonged mouse survival after botulism neurotoxin A intoxication.

Graphical abstract: Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication

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Article information


Submitted
21 Jan 2016
Accepted
17 Feb 2016
First published
18 Feb 2016

Chem. Commun., 2016,52, 4187-4190
Article type
Communication
Author version available

Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication

T. L. Harris, C. J. Wenthur, A. Diego-Taboada, G. Mackenzie, T. S. Corbitt and K. D. Janda, Chem. Commun., 2016, 52, 4187
DOI: 10.1039/C6CC00615A

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