Jump to main content
Jump to site search

Issue 39, 2015
Previous Article Next Article

Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

Author affiliations

Abstract

The recently developed poly(glycerol sebacate) (PGS) has been gaining attraction as a biomaterial for tissue engineering applications. Reported in 2002, a simple polycondensation method was developed to synthesize PGS for soft tissue engineering applications. It has since become a highly sought after biomaterial due to its soft, robust and flexible characteristics and it is relatively low cost compared to other biodegradable elastomers currently available in the market. We summarise in this review, the various synthetic approaches of PGS and highlight selected applications in nerve guidance, soft tissue regeneration, vascular and myocardial tissue regeneration, blood vessel reconstruction, drug delivery, and the replacement of photoreceptor cells. A critical assessment of the material is provided as a scope for future improvement. The future outlook of this material is also provided at the end of this review.

Graphical abstract: Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

Back to tab navigation

Article information


Submitted
31 May 2015
Accepted
11 Aug 2015
First published
12 Aug 2015

J. Mater. Chem. B, 2015,3, 7641-7652
Article type
Review Article

Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

X. J. Loh, A. Abdul Karim and C. Owh, J. Mater. Chem. B, 2015, 3, 7641 DOI: 10.1039/C5TB01048A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements