Issue 39, 2015
From the journal:

Journal of Materials Chemistry B

Self-assembly of bi-functional peptides on large-pore mesoporous silica nanoparticles for miRNA binding and delivery†

Jingxiong Lu,a   Hsin-Hui Shen,*b   Zhangxiong Wu,c   Bo Wang,d   Dongyuan Zhaoae  and  Lizhong He*a  

* Corresponding authors

a Department of Chemical Engineering, Monash University, Wellington Road, Melbourne 3800, Australia
E-mail: lizhong.he@monash.edu

b Department of Microbiology, Monash University, Wellington Road, Melbourne 3800, Australia
E-mail: hsin-hui.shen@monash.edu

c College of Chemistry Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, P. R. China

d Department of Anatomy and Developmental Biology, Monash University, Wellington Road, Melbourne 3800, Australia

e Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, and Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China

Abstract

Bi-functional peptides were designed to have binding abilities for both silica nanoparticles and miRNAs. Non-covalent self-assembly of peptides on large pore mesoporous silica nanoparticles provides a delivery system that shows a high binding capacity for nucleic acids, strong transfection efficiency of miRNA and attractive down-regulation of protein expression.

Graphical abstract: Self-assembly of bi-functional peptides on large-pore mesoporous silica nanoparticles for miRNA binding and delivery

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Article information

DOI
https://doi.org/10.1039/C5TB01133G
Article type
Communication
Submitted
12 Jun 2015
Accepted
09 Sep 2015
First published
11 Sep 2015

J. Mater. Chem. B, 2015,3, 7653-7657

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Self-assembly of bi-functional peptides on large-pore mesoporous silica nanoparticles for miRNA binding and delivery

J. Lu, H. Shen, Z. Wu, B. Wang, D. Zhao and L. He, J. Mater. Chem. B, 2015, 3, 7653 DOI: 10.1039/C5TB01133G

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