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Issue 25, 2015
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Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

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Abstract

Two azide-functionalized tetraphenylethene derivatives with AIE features are synthesized and used as fluorescent agents for detecting S-phase DNA synthesis and cell proliferation based on EdU assay. Compared to the Alexa-azide dye, a commercial DNA bioprobe, the AIE fluorogens show better photostability and sensitivity, making them promising alternatives.

Graphical abstract: Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

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Publication details

The article was received on 12 Mar 2015, accepted on 14 Apr 2015 and first published on 14 Apr 2015


Article type: Communication
DOI: 10.1039/C5TB00458F
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J. Mater. Chem. B, 2015,3, 4993-4996

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    Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

    Y. Zhao, C. Y. Y. Yu, R. T. K. Kwok, Y. Chen, S. Chen, J. W. Y. Lam and B. Z. Tang, J. Mater. Chem. B, 2015, 3, 4993
    DOI: 10.1039/C5TB00458F

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