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Issue 13, 2015
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The synthesis and characterisation of strontium and calcium folates with potential osteogenic activity

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Abstract

Compounds having the general formula MFO·4H2O where M = Ca or Sr and FO = a folate anion were prepared and their structure and physico-chemical properties were determined by elemental and thermal TGA, DSC analysis, FTIR, and EDAX spectroscopies and DRX. The results indicate that the two compounds form stable structures where folic acid acts as a self-bridging ligand via two bidentate carboxylate groups. Moreover the two compounds showed a low toxicity in vitro response as h-osteoblast cell viability was not negatively affected by the presence of folate derivatives within the range of 0.063–0.5 mg ml−1. The results also indicate that the folate derivatives that are formed overcome the toxic effects related to free Sr2+ ions. The range of maximum cell viability corresponding with a concentration of SrFO falls within the in vitro physiologically active range for strontium while within the same range the strontium derivative showed a potential osteogenic activity as indicated by the overexpression of ALP activity.

Graphical abstract: The synthesis and characterisation of strontium and calcium folates with potential osteogenic activity

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Publication details

The article was received on 27 Nov 2014, accepted on 16 Feb 2015 and first published on 16 Feb 2015


Article type: Paper
DOI: 10.1039/C4TB01969E
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J. Mater. Chem. B, 2015,3, 2708-2713

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    The synthesis and characterisation of strontium and calcium folates with potential osteogenic activity

    L. Rojo, S. Radley-Searle, M. Fernandez-Gutierrez, L. M. Rodriguez-Lorenzo, C. Abradelo, S. Deb and J. San Roman, J. Mater. Chem. B, 2015, 3, 2708
    DOI: 10.1039/C4TB01969E

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