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Issue 10, 2015

A supramolecular nanovehicle toward systematic, targeted cancer and tumor therapy

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Abstract

A supramolecular nanovehicle (denoted as SNV) was fabricated by encapsulating zinc phthalocyanine (ZnPc) and doxorubicin (DOX) into a copolymer (PVP-b-PAA-g-FA), so as to achieve systematic and synergistic chemotherapy-photodynamic therapy (PDT), targeted tumor imaging and therapy. The sophisticated copolymer designed in this work can load the PDT photosensitizer (ZnPc) and chemotherapy drug (DOX) simultaneously, which exhibits an excellent performance in chemotherapy-PDT targeted cancer and tumor therapy for both in vitro studies performed with HepG2 cells and in vivo tests with mice. This work provides a new drug formulation with a chemotherapy-PDT synergistic effect by virtue of the supramolecular material design, which possesses the advantages of an ultra-low drug dosage and highly-efficient in vivo targeted tumor imaging/therapy.

Graphical abstract: A supramolecular nanovehicle toward systematic, targeted cancer and tumor therapy

Supplementary files

Article information


Submitted
19 Mar 2015
Accepted
22 Jun 2015
First published
22 Jun 2015

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2015,6, 5511-5518
Article type
Edge Article

A supramolecular nanovehicle toward systematic, targeted cancer and tumor therapy

R. Liang, S. You, L. Ma, C. Li, R. Tian, M. Wei, D. Yan, M. Yin, W. Yang, D. G. Evans and X. Duan, Chem. Sci., 2015, 6, 5511 DOI: 10.1039/C5SC00994D

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