Issue 128, 2015
From the journal:

RSC Advances

Silica gel-promoted practical synthesis of oxindole–nitrones from diazooxindoles and nitrosoarenes under solvent-free conditions†

Yun-Hao Zhang,a   Ming-Yue Wub  and  Wen-Cai Huang*a  

* Corresponding authors

a Department of Pharmaceutical and Bioengineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, P. R. China
E-mail: hwc@scu.edu.cn

b Department of Chemistry, South University of Science and Technology of China, Shenzhen 518055, P. R. China

Abstract

A practical method for the synthesis of oxindole–nitrones promoted by silica gel was developed with good results. The protocol is environmentally friendly as the reaction proceeds under solvent-free conditions with broad substrate scope, and high selectivity and chemical yield, and the silica gel can be quantitatively recovered and reused multiple times.

Graphical abstract: Silica gel-promoted practical synthesis of oxindole–nitrones from diazooxindoles and nitrosoarenes under solvent-free conditions

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Article information

DOI
https://doi.org/10.1039/C5RA21874H
Article type
Communication
Submitted
20 Oct 2015
Accepted
01 Dec 2015
First published
14 Dec 2015

RSC Adv., 2015,5, 105825-105828

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Silica gel-promoted practical synthesis of oxindole–nitrones from diazooxindoles and nitrosoarenes under solvent-free conditions

Y. Zhang, M. Wu and W. Huang, RSC Adv., 2015, 5, 105825 DOI: 10.1039/C5RA21874H

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