Domino synthesis of functionalized 1,6-naphthyridines and their in vitro anti-inflammatory and anti-oxidant efficacies

Abstract

Bioactive 1,6-naphthyridines were constructed through a one pot multicomponent method by reacting different ketones with malononitrile and pyrrolidine. In vitro anti-inflammatory and 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activities for all the synthesized 1,6-naphthyridines were further carried out. These results clearly show that compound 3e exhibited excellent anti-inflammatory activity with a percentage inhibition of 81.24 ± 4.46 by membrane stabilization method and 77.85 ± 0.46 by the albumin denaturation method at a concentration of 100 μg ml⁻¹, which is comparable to the standard diclofenac. A noticeable DPPH scavenging activity of 82.08 ± 1.81% was also observed for the synthesized compound 3e when compared with the standard, ascorbic acid.