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Issue 76, 2015
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Dual role of pinostrobin-a flavonoid nutraceutical as an efflux pump inhibitor and antibiofilm agent to mitigate food borne pathogens

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Abstract

Nutraceutical pinostrobin displayed synergy with ciprofloxacin against diverse bacteria causing drastic 128 fold reduction in ciprofloxacin MIC in MRSA and significant antibiofilm effect against E. coli and P. aeruginosa at subinhibitory concentrations. Studies with NorA mutants of S.aureus revealed efflux inhibition of pinostrobin is mediated by efflux pumps other than NorA.

Graphical abstract: Dual role of pinostrobin-a flavonoid nutraceutical as an efflux pump inhibitor and antibiofilm agent to mitigate food borne pathogens

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Supplementary files

Article information


Submitted
20 Apr 2015
Accepted
08 Jul 2015
First published
13 Jul 2015

RSC Adv., 2015,5, 61881-61887
Article type
Communication
Author version available

Dual role of pinostrobin-a flavonoid nutraceutical as an efflux pump inhibitor and antibiofilm agent to mitigate food borne pathogens

L. R. Christena, S. Subramaniam, M. Vidhyalakshmi, V. Mahadevan, A. Sivasubramanian and S. Nagarajan, RSC Adv., 2015, 5, 61881
DOI: 10.1039/C5RA07165H

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