Issue 76, 2015
From the journal:

RSC Advances

A mild CuBr–NMO oxidative system for the coupling of anilines leading to aromatic azo compounds†

Shikha Singh,a   Parul Chauhan,a   Makthala Ravi,a   Isha Taneja,b   Wahajuddinb  and  Prem. P. Yadav*a  

* Corresponding authors

a Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow-226031, India
E-mail: pp_yadav@cdri.res.in, ppy_cdri@yahoo.co.in
Fax: +91-522-2771942/2771970
Tel: +91-522-2772450 ext. 4761

b Division of Pharmacokinetics and Metabolism, CSIR-Central Drug Research Institute, Lucknow-226031, India

Abstract

An efficient, mild and cost-effective method has been developed utilizing CuBr with N-methylmorpholine N-oxide (NMO/NMMO) for the oxidative coupling of anilines to access symmetrical and unsymmetrical azo compounds in high yield. The reactivity was found to be governed by electronic and steric factors of anilines.

Graphical abstract: A mild CuBr–NMO oxidative system for the coupling of anilines leading to aromatic azo compounds

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Article information

DOI
https://doi.org/10.1039/C5RA12535A
Article type
Communication
Submitted
29 Jun 2015
Accepted
10 Jul 2015
First published
10 Jul 2015

RSC Adv., 2015,5, 61876-61880

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A mild CuBr–NMO oxidative system for the coupling of anilines leading to aromatic azo compounds

S. Singh, P. Chauhan, M. Ravi, I. Taneja, Wahajuddin and Prem. P. Yadav, RSC Adv., 2015, 5, 61876 DOI: 10.1039/C5RA12535A

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