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Issue 41, 2015
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Tuneable pH-regulated supramolecular copolymerisation by mixing mismatched dendritic peptide comonomers

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Abstract

Charged phenylalanine-rich dendritic peptides form highly stable and pH-switchable rod-like supramolecular copolymers, when co-assembled with a matching oppositely charged dendritic comonomer. Here, we demonstrate that by mismatching a strong with a weak β-sheet encoded comonomer, both the stability and the pH-triggered disassembly of the copolymers shifts drastically from pH 4.2 to biologically relevant pH 5.8.

Graphical abstract: Tuneable pH-regulated supramolecular copolymerisation by mixing mismatched dendritic peptide comonomers

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Publication details

The article was received on 05 Aug 2015, accepted on 17 Aug 2015 and first published on 18 Aug 2015


Article type: Communication
DOI: 10.1039/C5PY01241D
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Citation: Polym. Chem., 2015,6, 7245-7250
  • Open access: Creative Commons BY-NC license
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    Tuneable pH-regulated supramolecular copolymerisation by mixing mismatched dendritic peptide comonomers

    P. Ahlers, H. Frisch and P. Besenius, Polym. Chem., 2015, 6, 7245
    DOI: 10.1039/C5PY01241D

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