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Issue 44, 2015
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Chelate cooperativity effects on the formation of di- and trivalent pseudo[2]rotaxanes with diketopiperazine threads and tetralactam wheels

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Abstract

The formation of singly, doubly and triply threaded pseudo[2]rotaxanes with diketopiperazine threads and tetralactam wheels is investigated with respect to chelate cooperativity effects on multivalent binding. Two series of guest molecules are prepared which differ with respect to their spacers, one with preorganised centrepieces with di- or tripodal roof-like structures, one with more flexible spacers. The thermodynamics of pseudorotaxane formation is examined using isothermal titration calorimetry and 1H NMR spectroscopy. Force-field calculations provide more detailed structural insight and help rationalizing the thermodynamic data. All di- and trivalent pseudorotaxanes exhibit positive chelate cooperativity presumably arising from spacer–spacer interactions. Higher cooperativity factors are observed for the more preorganised threads.

Graphical abstract: Chelate cooperativity effects on the formation of di- and trivalent pseudo[2]rotaxanes with diketopiperazine threads and tetralactam wheels

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Article information


Submitted
11 Aug 2015
Accepted
07 Sep 2015
First published
07 Sep 2015

Org. Biomol. Chem., 2015,13, 10881-10887
Article type
Paper

Chelate cooperativity effects on the formation of di- and trivalent pseudo[2]rotaxanes with diketopiperazine threads and tetralactam wheels

N. L. Traulsen, C. H.-H. Traulsen, P. M. Deutinger, S. Müller, D. Schmidt, I. Linder and C. A. Schalley, Org. Biomol. Chem., 2015, 13, 10881
DOI: 10.1039/C5OB01687H

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