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Issue 39, 2015
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Total syntheses of natural products containing spirocarbocycles

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Abstract

The structures of natural products from a variety of sources contain spirocycles, two rings that share a common atom. The spiro motif is finding increasing inclusion in drug candidates, and as a structural component in several promising classes of chiral ligands used in asymmetric synthesis. Total syntheses of products containing all-carbon spirocycles feature several common methods of ring closure which we examine in this review.

Graphical abstract: Total syntheses of natural products containing spirocarbocycles

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Publication details

The article was received on 23 Jul 2015, accepted on 01 Sep 2015 and first published on 01 Sep 2015


Article type: Review Article
DOI: 10.1039/C5OB01524C
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Citation: Org. Biomol. Chem., 2015,13, 9907-9933
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    Total syntheses of natural products containing spirocarbocycles

    L. K. Smith and I. R. Baxendale, Org. Biomol. Chem., 2015, 13, 9907
    DOI: 10.1039/C5OB01524C

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