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Issue 39, 2015
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Emerging trends in enzyme inhibition by multivalent nanoconstructs

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Abstract

Multivalent nanoconstructs, extensively used for enhancing the recognition of biomolecular targets, have been recently exploited for enzyme inhibition showing interesting properties such as improvement of inhibitory potency and selectivity. We review herein the recent results highlighting the potential of multivalent nanoconstructs for the inhibition of different enzymes, and the emerging trends in the generation and identification of multivalent clusters as enzyme inhibitors.

Graphical abstract: Emerging trends in enzyme inhibition by multivalent nanoconstructs

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Publication details

The article was received on 10 Jul 2015, accepted on 24 Aug 2015 and first published on 24 Aug 2015


Article type: Review Article
DOI: 10.1039/C5OB01405K
Citation: Org. Biomol. Chem., 2015,13, 9894-9906
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    Emerging trends in enzyme inhibition by multivalent nanoconstructs

    N. Kanfar, E. Bartolami, R. Zelli, A. Marra, J. Winum, S. Ulrich and P. Dumy, Org. Biomol. Chem., 2015, 13, 9894
    DOI: 10.1039/C5OB01405K

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