Issue 35, 2015

A facile approach to the synthesis of structurally diverse 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives via a three-component domino reaction

Abstract

A concise and efficient approach to the synthesis of structurally diverse 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives has been accomplished by a three-component reaction involving sulfonyl acetonitrile, an aromatic aldehyde, and 6-aminouracil. The method involves the domino Knoevenagel condensation/Michael addition/cyclization cascade in the presence of triethylamine in refluxing ethanol.

Graphical abstract: A facile approach to the synthesis of structurally diverse 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives via a three-component domino reaction

Supplementary files

Article information

Article type
Communication
Submitted
18 Jul 2015
Accepted
31 Jul 2015
First published
31 Jul 2015

Org. Biomol. Chem., 2015,13, 9181-9185

Author version available

A facile approach to the synthesis of structurally diverse 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives via a three-component domino reaction

Y. Dommaraju, S. Bora and D. Prajapati, Org. Biomol. Chem., 2015, 13, 9181 DOI: 10.1039/C5OB01484K

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