Issue 35, 2015
From the journal:

Organic & Biomolecular Chemistry

Rh(iii)-catalyzed cyclization reaction of azoles with alkynes: efficient synthesis of azole-fused-pyridines†

Xuebing Chen,a   Youzhi Wu,a   Jinyi Xu,a   Hequan Yao,a   Aijun Lina  and  Yue Huang*ab  

* Corresponding authors

a State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, P. R. China

b Department of Organic Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, P. R. China
E-mail: yhuang@cpu.edu.cn

Abstract

A Rh(III)-catalyzed cyclization of azoles with alkynes has been developed. A variety of azole-fused-pyridines were obtained in good to excellent yields and regioselectivity. Both the C5 and the C4 position of azoles were suitable for the reaction.

Graphical abstract: Rh(iii)-catalyzed cyclization reaction of azoles with alkynes: efficient synthesis of azole-fused-pyridines

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Article information

DOI
https://doi.org/10.1039/C5OB01338K
Article type
Communication
Submitted
01 Jul 2015
Accepted
27 Jul 2015
First published
27 Jul 2015

Org. Biomol. Chem., 2015,13, 9186-9189

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Rh(III)-catalyzed cyclization reaction of azoles with alkynes: efficient synthesis of azole-fused-pyridines

X. Chen, Y. Wu, J. Xu, H. Yao, A. Lin and Y. Huang, Org. Biomol. Chem., 2015, 13, 9186 DOI: 10.1039/C5OB01338K

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