Issue 34, 2015
From the journal:

Organic & Biomolecular Chemistry

Cu-mediated direct regioselective C-2 chlorination of indoles†

Jing Zhao,a   Xiuzhi Cheng,a   Jun Le,a   Wei Yang,b   Fengtian Xue,b   Xuan Zhangc  and  Chao Jiang*a  

* Corresponding authors

a Department of Pharmaceutical Engineering, School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu, China
E-mail: chaojiang@njust.edu.cn

b Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, Maryland 21201, United States

c Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, Nanjing University of Science & Technology, Nanjing, Jiangsu, China

Abstract

Cu-mediated C-2 chlorination of indoles was accomplished with copper(II) chloride through the use of a directing pyrimidyl protection group. A highly regioselective manner can be achieved on a range of indole substrates with excellent functional group tolerance.

Graphical abstract: Cu-mediated direct regioselective C-2 chlorination of indoles

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Article information

DOI
https://doi.org/10.1039/C5OB01228G
Article type
Communication
Submitted
16 Jun 2015
Accepted
27 Jul 2015
First published
30 Jul 2015

Org. Biomol. Chem., 2015,13, 9000-9004

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Cu-mediated direct regioselective C-2 chlorination of indoles

J. Zhao, X. Cheng, J. Le, W. Yang, F. Xue, X. Zhang and C. Jiang, Org. Biomol. Chem., 2015, 13, 9000 DOI: 10.1039/C5OB01228G

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