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Issue 24, 2015
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Mitochondrially targeted redox probe reveals the variations in oxidative capacity of the haematopoietic cells

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Abstract

Both oxidative stress and mitochondrial dysfunction play roles in a myriad of pathological conditions. There is therefore a need for tools that possess the ability to measure the dynamics of oxidative capacity within the mitochondria, particularly those that can measure reversible changes. Here, we report a mitochondrially-targeted fluorescent redox sensor NpFR2, which can reversibly measure changes in the mitochondrial redox environment. The probe has been used to report on variations in oxidative capacity of the haematopoietic cells in bone marrow, thymus and spleen.

Graphical abstract: Mitochondrially targeted redox probe reveals the variations in oxidative capacity of the haematopoietic cells

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Supplementary files

Article information


Submitted
07 May 2015
Accepted
18 May 2015
First published
26 May 2015

Org. Biomol. Chem., 2015,13, 6686-6689
Article type
Communication
Author version available

Mitochondrially targeted redox probe reveals the variations in oxidative capacity of the haematopoietic cells

A. Kaur, K. W. L. Brigden, T. F. Cashman, S. T. Fraser and E. J. New, Org. Biomol. Chem., 2015, 13, 6686
DOI: 10.1039/C5OB00928F

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