Yucai Tang, Ye Zhang, Kaifeng Wang, Xiaoqing Li, Xiangsheng Xu and Xiaohua Du
Org. Biomol. Chem., 2015,13, 7084-7090
DOI:
10.1039/C5OB00742A,
Paper
A facile synthetic route towards pharmaceutically interesting β-keto-sulfone derivatives by tetrabutylammonium iodide (TBAI)/tert-butyl hydroperoxide (TBHP) mediated oxidative coupling of readily prepared enamides with economical sulfonylhydrazides is described. The corresponding β-keto-sulfone compounds were obtained in moderate to good yields. The present method is metal-free and base-free and shows tolerance to a variety of functional groups.
