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Issue 13, 2015
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Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells

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Abstract

Crispene E, a new clerodane-type diterpene, inhibited STAT3 dimerization in a cell-free fluorescent polarisation assay and was found to have significant toxicity against STAT3-dependent MDA-MB 231 breast cancer cell line and selectively inhibited the expression of STAT3 and STAT3 target genes cyclin D1, Fascin and bcl-2. Molecular docking studies suggest the molecule inhibits STAT3 by interacting with its SH2 domain. The compound has been isolated from Tinospora crispa and characterized using standard spectroscopic techniques.

Graphical abstract: Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells

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Supplementary files

Article information


Submitted
10 Jan 2015
Accepted
16 Feb 2015
First published
16 Feb 2015

Org. Biomol. Chem., 2015,13, 3882-3886
Article type
Communication
Author version available

Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells

J. Mantaj, S. M. A. Rahman, B. Bokshi, C. M. Hasan, P. J. M. Jackson, R. B. Parsons and K. M. Rahman, Org. Biomol. Chem., 2015, 13, 3882
DOI: 10.1039/C5OB00052A

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