Issue 2, 2015

Anion binding by biotin[6]uril in water


In this contribution we show that the newly discovered 6 + 6 biotin-formaldehyde macrocycle Biotin[6]uril binds a variety of anionic guest molecules in water. We discuss how and why the anions are bound based on data obtained using NMR spectroscopy, mass spectrometry, isothermal titration calorimetry (ITC), computational calculations and single crystal X-ray crystallography.

Graphical abstract: Anion binding by biotin[6]uril in water

Supplementary files

Article information

Article type
17 Oct 2014
12 Nov 2014
First published
19 Nov 2014
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2015,13, 369-373

Author version available

Anion binding by biotin[6]uril in water

M. Lisbjerg, B. E. Nielsen, B. O. Milhøj, S. P. A. Sauer and M. Pittelkow, Org. Biomol. Chem., 2015, 13, 369 DOI: 10.1039/C4OB02211D

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