Issue 2, 2015

Bioorthogonal labelling of 3-nitrotyrosine in peptides and proteins through diazotisation mediated azidation

Abstract

A new chemical derivatisation method to functionalise peptide and protein bound 3-nitrotyrosine residues is described. By transforming 3-nitrotyrosine to 3-azidotyrosine, the method enables ‘click chemistry’-based labelling of the 3-nitrotyrosine residues and provides new opportunities for the study of this post-translational modification in biological samples.

Graphical abstract: Bioorthogonal labelling of 3-nitrotyrosine in peptides and proteins through diazotisation mediated azidation

Supplementary files

Article information

Article type
Communication
Submitted
07 Oct 2014
Accepted
11 Nov 2014
First published
11 Nov 2014

Org. Biomol. Chem., 2015,13, 374-378

Author version available

Bioorthogonal labelling of 3-nitrotyrosine in peptides and proteins through diazotisation mediated azidation

J. Y. Ng and J. W. H. Wong, Org. Biomol. Chem., 2015, 13, 374 DOI: 10.1039/C4OB02133A

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