I2-Catalyzed diamination of acetyl-compounds for the synthesis of multi-substituted imidazoles

Jinpeng Qu; Ping Wu; Dong Tang; Xu Meng; Yongxin Chen; Shuaibo Guo; Baohua Chen

doi:10.1039/C5NJ00910C

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I₂-Catalyzed diamination of acetyl-compounds for the synthesis of multi-substituted imidazoles†

Jinpeng Qu,^ab Ping Wu,^ab Dong Tang,^ab Xu Meng,^c Yongxin Chen,^d Shuaibo Guo^ab and Baohua Chen*^ab

Author affiliations

* Corresponding authors

^a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu, P. R. China

^b Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou, P. R. China
E-mail: chbh@lzu.edu.cn
Fax: + 86(931)8912582

^c State Key Laboratory of Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P. R. China

^d Key Laboratory of Petroleum Resources Research, Institute of Geology and Geophysics, Lanzhou 730000, China

Abstract

An expedient and straightforward synthetic route to substituted imidazole derivatives from amidines and ketones catalyzed by I₂ has been reported. The reaction proceeded smoothly, and a series of imidazole scaffolds were produced in good to excellent yields and 100% regioselectivity.

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Article information

DOI: https://doi.org/10.1039/C5NJ00910C
Article type: Letter
Submitted: 13 Apr 2015
Accepted: 21 Apr 2015
First published: 22 Apr 2015

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New J. Chem., 2015,39, 4235-4239

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I₂-Catalyzed diamination of acetyl-compounds for the synthesis of multi-substituted imidazoles

J. Qu, P. Wu, D. Tang, X. Meng, Y. Chen, S. Guo and B. Chen, New J. Chem., 2015, 39, 4235 DOI: 10.1039/C5NJ00910C

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