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Issue 9, 2015
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Synthesis and antimicrobial activity of aminoglycoside-conjugated silica nanoparticles against clinical and resistant bacteria

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Abstract

Functionalization of silica nanoparticles with different cationic moieties makes them suitable for being an effective antimicrobial agent against various clinical pathogenic microbes. Here, we report the synthesis, characterization and evaluation of aminoglycoside-conjugated silica nanoparticles [S–X NPs, where X = gentamicin (G), neomycin (N) or kanamycin (K)] for their antimicrobial activity against clinical pathogens and kanamycin-resistant E. coli. These functionalized silica nanoparticles exhibited enhanced broad-spectrum antimicrobial activity against clinical Gram-positive and Gram-negative bacteria as well as kanamycin-resistant E. coli strain with minimal cytotoxicity. The results show the potential of these conjugates to combat drug resistance.

Graphical abstract: Synthesis and antimicrobial activity of aminoglycoside-conjugated silica nanoparticles against clinical and resistant bacteria

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Supplementary files

Article information


Submitted
02 Jan 2015
Accepted
08 Apr 2015
First published
10 Apr 2015

New J. Chem., 2015,39, 6746-6755
Article type
Paper
Author version available

Synthesis and antimicrobial activity of aminoglycoside-conjugated silica nanoparticles against clinical and resistant bacteria

S. Agnihotri, R. Pathak, D. Jha, I. Roy, H. K. Gautam, A. K. Sharma and P. Kumar, New J. Chem., 2015, 39, 6746
DOI: 10.1039/C5NJ00007F

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